Mykhaylo Artamonov, PhD
Scientist
PhD in Biochemistry, Palladin Institute of Biochemistry, Kyiv, Ukraine
My current research interests are focused on understanding of integration profiles of HIV-1 and SIV viruses into human and Rhesus macaque genomes respectively. Another area of interests transcriptomic analysis of the host CD4 T cells on acute stages of infection.
As techniques I am applying flow cytometry analysis and flow sorting, different cellular and molecular biology methods, library preparation for short- and long-read sequencing with subsequent analysis.
| Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress. Wolpe AG, Luse MA, Baryiames C, Schug WJ, Wolpe JB, Johnstone SR, Dunaway LS, Juśkiewicz ZJ, Loeb SA, Askew Page HR, Chen YL, Sabapathy V, Pavelec CM, Wakefield B, Cifuentes-Pagano E, Artamonov MV, Somlyo AV, Straub AC, Sharma R, Beier F, Barrett EJ, Leitinger N, Pagano PJ, Sonkusare SK, Redemann S, Columbus L, Penuela S, Isakson BE. Sci Signal. 2024 Jan 30;17(821) |
| p90RSK2, a new MLCK mediates contractility in myosin light chain kinase null smooth muscle. Kalra J, Artamonov M, Wang H, Franke A, Markowska Z, Jin L, Derewenda ZS, Ayon RJ, Somlyo A. Front Physiol. 2023 Sep 13;14:1228488. |
| Molecular probes of spike ectodomain and its subdomains for SARS-CoV-2 variants, Alpha through Omicron. Teng IT, Nazzari AF, Choe M, Liu T, Oliveira de Souza M, Petrova Y, Tsybovsky Y, Wang S, Zhang B, Artamonov M, Madan B, Huang A, Lopez Acevedo SN, Pan X, Ruckwardt TJ, DeKosky BJ, Mascola JR, Misasi J, Sullivan NJ, Zhou T, Kwong PD. PLoS One. 2022 May 24;17(5):e0268767. |
| RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger. Artamonov MV, Sonkusare SK, Good ME, Momotani K, Eto M, Isakson BE, Le TH, Cope EL, Derewenda ZS, Derewenda U, Somlyo AV. Sci Signal. 2018 Oct 30;11(554):eaar3924. |
| Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure. DeLalio LJ, Keller AS, Chen J, Boyce AKJ, Artamonov MV, Askew-Page HR, Keller TCS 4th, Johnstone SR, Weaver RB, Good ME, Murphy SA, Best AK, Mintz EL, Penuela S, Greenwood IA, Machado RF, Somlyo AV, Swayne LA, Minshall RD, Isakson BE. Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2065-2078. |
| Bacterial Expression, Purification and In Vitro Phosphorylation of Full-Length Ribosomal S6 Kinase 2 (RSK2). Utepbergenov D, Hennig PM, Derewenda U, Artamonov MV, Somlyo AV, Derewenda ZS. PLoS One. 2016 Oct 12;11(10):e0164343. |
| A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells. Billaud M, Chiu YH, Lohman AW, Parpaite T, Butcher JT, Mutchler SM, DeLalio LJ, Artamonov MV, Sandilos JK, Best AK, Somlyo AV, Thompson RJ, Le TH, Ravichandran KS, Bayliss DA, Isakson BE. Sci Signal. 2015 Feb 17;8(364):ra17. |
| Signaling pathways that control rho kinase activity maintain the embryonic epicardial progenitor state. Artamonov MV, Jin L, Franke AS, Momotani K, Ho R, Dong XR, Majesky MW, Somlyo AV. J Biol Chem. 2015 Apr 17;290(16):10353-67. |
| Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure. Lakshmikanthan S, Zieba BJ, Ge ZD, Momotani K, Zheng X, Lund H, Artamonov MV, Maas JE, Szabo A, Zhang DX, Auchampach JA, Mattson DL, Somlyo AV, Chrzanowska-Wodnicka M. Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1486-94. |
| Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction. Straub AC, Butcher JT, Billaud M, Mutchler SM, Artamonov MV, Nguyen AT, Johnson T, Best AK, Miller MP, Palmer LA, Columbus L, Somlyo AV, Le TH, Isakson BE. Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2594-600. |
| The p90 ribosomal S6 kinase (RSK) is a mediator of smooth muscle contractility. Artamonov M, Momotani K, Utepbergenov D, Franke A, Khromov A, Derewenda ZS, Somlyo AV. PLoS One. 2013;8(3):e58703. |
| p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility. Momotani K, Artamonov MV, Utepbergenov D, Derewenda U, Derewenda ZS, Somlyo AV. Circ Res. 2011 Oct 14;109(9):993-1002. |
| Host derived inflammatory phospholipids regulate rahU (PA0122) gene, protein, and biofilm formation in Pseudomonas aeruginosa. Rao J, DiGiandomenico A, Artamonov M, Leitinger N, Amin AR, Goldberg JB. Cell Immunol. 2011;270(2):95-102. |
Area of Research
Institution Affiliations
WRAIR in support of U.S. Military HIV Research Program