Michael Rouse, PhD
As the Associate Director of Laboratory Science and Operations for Surgical Critical Care Initiative (SC2i) and the Walter Reed National Military Medical Center (WRNMMC), I lead and manage interdisciplinary and cross-functional teams across a broad range of scientific areas to promote product development and maximize clinical outcomes requiring complex medical decision making.
My laboratory is GCLP, CAP-Biorepository, and CLIP accredited. We routinely collaborate and use multi-omics (proteins, transcripts, genomics) approaches to manage and facilitate the development of biomarker-driven Clinical Decision Support Tools (CDSTs), such as advanced analytics, machine learning, and precision medicine diagnostics.
I am primarily focused on identifying biomarkers and developing new assays/technologies to better understand the translational mechanisms and improve clinical outcomes of combat-related injuries and conditions.
| Schobel SA, Gann ER, Unselt D, Grey SF, Lisboa FA, Upadhyay MM, Rouse M, Tallowin S, Be NA, Zhang X, Dalgard CL, Wilkerson MD, Hauskrecht M, Badylak SF, Zamora R, Vodovotz Y, Potter BK, Davis TA, Elster EA. 2024. The influence of microbial colonization on inflammatory versus pro-healing trajectories in combat extremity wounds. Sci Rep. 2024.14(1):5006. doi: 10.1038/s41598-024-52479-5. |
| Li R, Rouse M, Pace BT, Grey SF, Mclaughlin K, Schobel SA, Simons MP. Host CD3+ T-cells can significantly modulate phage treatment effects on bacterial bioburden in mouse models. Frontiers in Microbiol. 2023. 14:1240176. |
| Bergmann-Leitner, E., Bobrov, A.G., Bolton, J.S., Rouse, M., D., Heyburn, L., Pavlovic, R., Garry, B.I., Alamneh, Y., Long, J., Swierczewski, B., Tyner, S., Getnet, D., Sajja, V.J., Antonic, V. 2022. Blast Waves Cause Immune System Dysfunction and Transient Bone Marrow Failure in a Mouse Model. Frontiers Bioengineering. 10:821169. |
| Rouse, M., Stanbro, J. Roman, J.A., Lipinski, M., Jacobs, A., Biswas, B., Regeimbal, J., Henry, M., Stockelman, M.G., Simons, M.P. 2020. Impact of Frequent Administration of Bacteriophage on Therapetuic Efficacy in an A. baumannii Mouse Wound Infection Model. Frontiers in Microbiol. 11:414. |
| Jacobs, A., Dugan, J., Duplessis, C., Rouse, M., Deshotel, M., Simons, M., Biswas, B., Nikolich, M., Stockelman, M., Tyner, S., Demons, S., Watters, C. 2018. “Practical Applications of Bacteriophage Therapy: Biofilms to Bedside. In "Antibacterial Drug Discovery to combat MDR - Natural Compounds, Nanotechnology and Novel Synthetic Sources.” (I. Ahmad, and K. Rumbaugh, editors). Springer, New York, NY. Antibacterial Drug Discovery to Combat MDR |
| Rouse M., Younes A., Egan J.M. 2014. Resveratrol and curcumin enhance pancreatic beta-cell function by inhibiting phosphodiesterase activity. J Endocrinol. S0303-7207(15): 30171-30174. 3-7207(15): 30171-30174. |
Area of Research
Institution Affiliations
HJF Associate Director of Laboratory Science and Operations, SC2i and Assistant Professor of Surgery in support of Uniformed Services University