Pathogen agnostic strategies are an attractive medical countermeasure for both the warfighter and civilian populations. The human host response is a sensitive and specific reporter for critical illness. My view is that host-based approaches will provide translational solutions to improve outcomes in patients with sepsis or severe infections. The development of host-directed therapeutics will be facilitated through clinical research efforts that study large numbers of human subjects with disease to drive the process of discovery and translation. My current research efforts are focused on the application of multiomics technologies and functional assays to define the pathobiology of critical illness in global clinical cohorts. I currently lead a team of molecular and computational biologists and mathematicians that are developing new tools and strategies to achieve these research goals.
Postdoctoral Fellowship, NINDS
| Chenoweth JG, Brandsma J, Striegel DA, Genzor P, Chiyka E, Blair PW, Krishnan S, Dogbe E, Boakye I, Fogel GB, Tsalik EL, Woods CW, Owusu-Ofori A, Oppong C, Oduro G, Vantha T, Letizia AG, Beckett CG, Schully KL, Clark DV. Sepsis endotypes identified by host gene expression across global cohorts. Commun Med (Lond). 2024 Jun 18;4(1):120. doi: 10.1038/s43856-024-00542-7. PMID: 38890515; PMCID: PMC11189468. |
| Chenoweth JG, Colantuoni C, Striegel DA, Genzor P, Brandsma J, Blair PW, Krishnan S, Chiyka E, Fazli M, Mehta R, Considine M, Cope L, Knight AC, Elayadi A, Fox A, Hertzano R, Letizia AG, Owusu-Ofori A, Boakye I, Aduboffour AA, Ansong D, Biney E, Oduro G, Schully KL, Clark DV. Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes. Nat Commun. 2024 May 30;15(1):4606. doi: 10.1038/s41467-024-48821-0. PMID: 38816375; PMCID: PMC11139862. |
| Vashi B, Pettrone K, Wilson CS, Chenoweth JG, Brandsma J, Gregory MK, Genzor P, Striegel DA, Rothman RE, Hansoti B, Avornu GD, McBryde B, Zimmerman LR, Woods CW, Petzold EA, Cowden J, Nitayaphan S, Nasomsong W, Clark DV. COVID-19 symptom severity and duration among outpatients, July 2021-May 2023: The PROTECT observational study. PLoS One. 2025 Feb 21;20(2):e0314518. doi: 10.1371/journal.pone.0314518. PMID: 39982872; PMCID: PMC11844841. |
| Burke EE, Chenoweth JG, Shin JH, Collado-Torres L, Kim SK, Micali N, Wang Y, Colantuoni C, Straub RE, Hoeppner DJ, Chen HY, Sellers A, Shibbani K, Hamersky GR, Diaz Bustamante M, Phan BN, Ulrich WS, Valencia C, Jaishankar A, Price AJ, Rajpurohit A, Semick SA, Bürli RW, Barrow JC, Hiler DJ, Page SC, Martinowich K, Hyde TM, Kleinman JE, Berman KF, Apud JA, Cross AJ, Brandon NJ, Weinberger DR, Maher BJ, McKay RDG, Jaffe AE. Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs. Nat Commun. 2020 Jan 23;11(1):462. doi: 10.1038/s41467-019-14266-z. PMID: 31974374; PMCID: PMC6978526. |
Institution Affiliations
HJF Director, Experimental and Translational Biology in support of the Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO)