Infectious Disease

Infectious disease remains a threat to the health and readiness of U.S. troops. HJF is collaborating on research efforts to develop novel diagnostic tests and countermeasures for the detection, prevention and treatment of infectious diseases.

 

U.S. Military HIV Research Program

HJF partners with the U.S. Military HIV Research Program (MHRP) to spearhead an international collaborative research effort focused on the prevention, care and treatment of HIV/AIDS.

Scientific, technical and administrative personnel from HJF work closely with the Walter Reed Army Institute of Research on HIV vaccine development. This partnership has enabled the program to develop a robust international HIV clinical trial capability in several African nations as well as Thailand while providing prevention, care and treatment services in these countries.

The program’s RV144 HIV vaccine trial in Thailand in 2009, showed a vaccine regimen was safe and modestly effective in preventing HIV infection, a result that and propelled MHRP to the forefront of HIV vaccine development. The program partners with private industry, the Bill & Melinda Gates Foundation, and the National Institute of Allergy and Infectious Diseases in follow-up studies.

Infectious Disease Clinical Research Program

Founded in 2005 under an interagency agreement between the Uniformed Service University of the Health Sciences and the National Institute of Allergy and Infectious Diseases, the Infectious Disease Clinical Research Program has grown into a multi-site clinical research network supporting numerous observational studies in military populations.

HJF provides program management, scientific and technical personnel, as well as administrative and logistical support coordinating all the program’s performance sites. The center conducts protocols that address the critical gaps in managing and preventing infectious diseases in the military.

Navy Malaria Program

Scientists at the Naval Medical Research Center are at the forefront of malaria research worldwide. From vaccine research to identifying hot spots, HJF supports efforts to eradicate the deadly parasite, with the ultimate goal of developing a vaccine that kills the parasite during its first few days of development in the body.

The center is exploring promising vaccine approaches, including a gene-based approach with a DNA prime-adenovirus boost malaria vaccine that protected a small number of people against malaria infection and an attenuated whole parasite approach that provided high levels of protection.

Military Malaria Research Program

HJF provides proposal development, technical, programmatic and administrative support for the Military Malaria Research Program (MMRP) at the Walter Reed Army Institute of Research. HJF supports both malaria vaccine development and malaria drug development programs in MMRP.

HJF manages a human Phase I/IIa clinical trial of a nanoparticle malaria vaccine formulated in a liposome-based adjuvant. In addition, HJF supports the characterization and manufacture of newly identified triazine compounds as an anti-malarial prophylactic drug candidate for weekly dosing, and is assessing its safety and preliminary efficacy in human clinical trials.

Austere environments Consortium for Enhanced Sepsis Outcomes

Military personnel are at particular risk of sepsis when deployed to austere regions with limited resources. HJF partners with NMRC to provide clinical and scientific expertise and programmatic and coordination support for the Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO).

ACESO aims to improve the survival for patients with sepsis through early recognition, diagnosis and evidence-based clinical management guidelines.

U.S. Air Force School of Aerospace Medicine Flu Surveillance Program

The United States Air Force School of Aerospace Medicine promotes readiness and protects force and community health by using a range of tools and expertise, including:

  • environmental and health surveillance
  • laboratory and risk analysis
  • process re-engineering, consultation
  • technological innovation.

HJF provided program management, molecular laboratory, data analytics, bioinformatics and epidemiological support to the school’s Flu Surveillance Program. HJF’s partnership helped the school to provide the Centers for Disease Control and Prevention with valuable data for informing annual flu vaccine strain selection.

Operational Infectious Diseases Department, Naval Health Research Center

HJF has extensive experience supporting the Operational Infectious Diseases Directorate Respiratory Disease Laboratory at the Naval Health Research Center while it functions as the Armed Forces Health Surveillance Branch, Global Emerging Infections Surveillance and Response System Navy hub.

HJF provides personnel for protocol-driven studies of emerging infectious diseases through the diagnosis and characterization of pathogens collected from clinical specimens during surveillance.

The directorate’s febrile respiratory infection and enteric disease surveillance includes shipboard, Pacific Rim, deployed, dependent and U.S./Mexican border populations. HJF conducts studies at Department of Defense recruit training centers and military treatment facilities.

Infectious Disease Surveillance at the U.S. Army Medical Research Directorate, Kenya

HJF assists the U.S. Army Medical Research Directorate, Kenya to conduct bench science, surveillance and testing of infectious disease medical countermeasures and diagnostics.

HJF works with the directorate to accomplish its mission in Kenya, Tanzania and Uganda, by facilitating partnerships with a wide range of important stakeholders in each country. In Kenya, HJF employees work with the Kenya Medical Research Institute and its scientists to ensure mission objectives are accomplished.